Joe Manganiello Credits Ex-Wife Sofia Vergara For Lifesaving Decision in Memoir

Joe Manganiello has opened up about a terrifying health crisis in his memoir, Bloodlines, released October 13, 2026. The 49-year-old True Blood alum revealed that his ex-wife, Sofia Vergara, made a brutal and lifesaving decision to remove his infected large intestine during emergency surgery while he was unconscious.

Manganiello stated that the operation left him with an ostomy bag and an uncertain future, but he believes he would not have survived without her intervention.

Health Struggles Following 2015 Marriage

In the memoir, the actor shared details about his years-long health struggle, noting that his health began to decline after he married Sofia Vergara in 2015. He experienced severe abdominal pain, ulcers, fevers, rashes, headaches, and constant fatigue, which led to years of medical uncertainty.